Skip to main content
SpringerLink
Log in

Immunology

Evolving superkines for selectivity

  • News & Views
  • Published:

From Nature Chemical Biology

View current issue Submit your manuscript

Combinatorial protein engineering based on structural data and the differential expression of alternate second receptor chains for interleukin-4 (IL-4) is used to modify and tune cellular specificity on primary human cells.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Hypothetical influence of relative receptor expressions on the activity of engineered cytokines.

References

  1. Juntilla, I.S. et al. Nat. Chem. Biol. 8, 990–998 (2012).

    Article  Google Scholar 

  2. Lee, Y.W., Eum, S.Y., Chen, K.C., Hennig, B. & Toborek, M. Mol. Med. 10, 19–27 (2004).

    Article  CAS  Google Scholar 

  3. Murata, T., Noguchi, P.D. & Puri, R.K. J. Biol. Chem. 270, 30829–30836 (1995).

    Article  CAS  Google Scholar 

  4. Prendiville, J. et al. Eur. J. Cancer 29A, 1700–1707 (1993).

    Article  CAS  Google Scholar 

  5. Rubin, J.T. & Lotze, M.T. Surgery 111, 274–280 (1992).

    CAS  PubMed  Google Scholar 

  6. Cutler, A. & Brombacher, F. Ann. NY Acad. Sci. 1056, 16–29 (2005).

    Article  CAS  Google Scholar 

  7. Gogas, H. et al. Anticancer Res. 24, 1947–1952 (2004).

    CAS  PubMed  Google Scholar 

  8. Kurtz, D.M. et al. Leuk. Lymphoma 48, 1290–1298 (2007).

    Article  CAS  Google Scholar 

  9. Swain, S.L., Weinberg, A.D. & English, M. J. Immunol. 144, 1788–1799 (1990).

    CAS  PubMed  Google Scholar 

  10. Shanafelt, A.B. et al. Proc. Natl. Acad. Sci. USA 95, 9454–9458 (1998).

    Article  CAS  Google Scholar 

  11. Pogue, S.L., Preston, B.T., Stalder, J., Bebbington, C.R. & Cardarelli, P.M. J. Interferon Cytokine Res. 24, 131–139 (2004).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Shane Miersch and Sachdev S. Sidhu are at the Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada.,

    Shane Miersch & Sachdev S Sidhu

Authors
  1. Shane Miersch
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sachdev S Sidhu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sachdev S Sidhu.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Miersch, S., Sidhu, S. Evolving superkines for selectivity. Nat Chem Biol 8, 955–956 (2012). https://doi.org/10.1038/nchembio.1119

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nchembio.1119

  • Springer Nature America, Inc.

Search

Navigation