Skip to main content
SpringerLink
Log in

Channels

Rotamers affect ion conductance

  • News & Views
  • Published:

From Nature Chemical Biology

View current issue Submit your manuscript

A major determinant of the ion flux rate through acetylcholine receptors is a ring of five residues, four glutamates and a glutamine, at the channel's cytoplasmic mouth. The glutamates adopt alternate rotamer conformations so that only two directly affect channel conductance.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Cys-loop receptor channel structure illustrated using the GluCl channel structure.

References

  1. Changeux, J.P. Annu. Rev. Pharmacol. Toxicol. 50, 1–38 (2010).

    Article  CAS  Google Scholar 

  2. Karlin, A. Nat. Rev. Neurosci. 3, 102–114 (2002).

    Article  CAS  Google Scholar 

  3. Bocquet, N. et al. Nature 457, 111–114 (2009).

    Article  CAS  Google Scholar 

  4. Hilf, R.J. & Dutzler, R. Nature 457, 115–118 (2009).

    Article  CAS  Google Scholar 

  5. Hibbs, R.E. & Gouaux, E. Nature 474, 54–60 (2011).

    Article  CAS  Google Scholar 

  6. Akabas, M.H., Kaufmann, C., Archdeacon, P. & Karlin, A. Neuron 13, 919–927 (1994).

    Article  CAS  Google Scholar 

  7. Imoto, K. et al. Nature 335, 645–648 (1988).

    Article  CAS  Google Scholar 

  8. Cymes, G.D. & Grosman, C. Nat. Chem. Biol. 8, 975–981 (2012).

    Article  CAS  Google Scholar 

  9. Goren, E.N., Reeves, D.C. & Akabas, M.H. J. Biol. Chem. 279, 11198–11205 (2004).

    Article  CAS  Google Scholar 

  10. Kelley, S.P., Dunlop, J.I., Kirkness, E.F., Lambert, J.J. & Peters, J.A. Nature 424, 321–324 (2003).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Myles H. Akabas is in the Departments of Physiology & Biophysics, Neuroscience and Medicine, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York, USA.,

    Myles H Akabas

Authors
  1. Myles H Akabas
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Myles H Akabas.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Akabas, M. Rotamers affect ion conductance. Nat Chem Biol 8, 953–954 (2012). https://doi.org/10.1038/nchembio.1115

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nchembio.1115

  • Springer Nature America, Inc.

Search

Navigation