Skip to main content
SpringerLink
Log in

Peptide inhibitors

Four of a kind beats a pair

  • News & Views
  • Published:

From Nature Chemical Biology

View current issue Submit your manuscript

The proapoptotic cysteine protease caspase-6 participates in the neuropathology of several diseases. Unlike the active dimeric form, the caspase-6 zymogen forms a unique tetramer that can be stabilized by allosteric inhibitors, which prevents caspase-6 activation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: The caspase-6 zymogen forms a tetramer that is stabilized by pep419.

References

  1. Fuentes-Prior, P. & Salvesen, G.S. Biochem. J. 384, 201–232 (2004).

    Article  CAS  Google Scholar 

  2. Stanger, K. et al. Nat. Chem. Biol. 8, 655–660 (2012).

    Article  CAS  Google Scholar 

  3. Guo, H. et al. Am. J. Pathol. 165, 523–531 (2004).

    Article  CAS  Google Scholar 

  4. Graham, R.K. et al. Cell 125, 1179–1191 (2006).

    Article  CAS  Google Scholar 

  5. Tebbenkamp, A.T. et al. Hum. Mol. Genet. 20, 2770–2782 (2011).

    Article  CAS  Google Scholar 

  6. Uribe, V. et al. Hum. Mol. Genet. 21, 1954–1967 (2012).

    Article  CAS  Google Scholar 

  7. Slee, E.A. et al. J. Cell Biol. 144, 281–292 (1999).

    Article  CAS  Google Scholar 

  8. Wang, X.J. et al. EMBO Rep. 11, 841–847 (2010).

    Article  CAS  Google Scholar 

  9. Hardy, J.A., Lam, J., Nguyen, J.T., O'Brien, T. & Wells, J.A. Proc. Natl. Acad. Sci. USA 101, 12461–12466 (2004).

    Article  CAS  Google Scholar 

  10. Baumgartner, R. et al. Biochem. J. 423, 429–439 (2009).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Shawn B. Bratton is in the Department of Molecular Carcinogenesis at the University of Texas– M.D. Anderson Cancer Center, Science Park, Smithville, Texas, USA.,

    Shawn B Bratton

Authors
  1. Shawn B Bratton
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Shawn B Bratton.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bratton, S. Four of a kind beats a pair. Nat Chem Biol 8, 606–607 (2012). https://doi.org/10.1038/nchembio.1000

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nchembio.1000

  • Springer Nature America, Inc.

Search

Navigation