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Molecularly imprinted polymers

Shaping enzyme inhibitors

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Small-molecule enzyme-inhibitors often display insufficient affinity and selectivity for their targets causing unwanted side effects when used as drugs. Molecularly imprinted polymers prepared using the enzyme as a template could offer a solution.

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Figure 1: Schematic of the synthesis of an enzyme-inhibiting molecularly imprinted polymer.

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Authors and Affiliations

  1. Börje Sellergren is at the Institute of Environmental Research, Dortmund University of Technology, Otto-Hahn Str. 6, D-44221 Dortmund, Germany. B.Sellergren@infu.uni-dortmund.de,

    Börje Sellergren

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  1. Börje Sellergren
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Sellergren, B. Shaping enzyme inhibitors. Nature Chem 2, 7–8 (2010). https://doi.org/10.1038/nchem.496

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