A pair of artificial DNA bases have now been shown to adopt an edge-to-edge geometry in DNA which is similar that found in Watson–Crick base pairing. Aptamers containing these bases have also been shown to bind more strongly to a target than those developed using only the four naturally occurring bases.
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Jung, C., Ellington, A. Six pack and stack. Nature Chem 7, 617–619 (2015). https://doi.org/10.1038/nchem.2313
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DOI: https://doi.org/10.1038/nchem.2313
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