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Getting a handle on peptides

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Enhancing the structural diversity of peptide natural products relies on synthetic modifications that are typically not chemo- or regioselective. A nonribosomal peptide synthetase has now been engineered to incorporate a non-natural amino acid containing a reactive bio-orthogonal handle.

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Figure 1: Biosynthesis of diketopiperazines (DKPs) using the wild-type or Trp239Ser-engineered nonribosomal peptide synthetase modules GrsA or TycA.

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Authors and Affiliations

  1. Jaclyn M. Winter and Yi Tang are in the Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, California 90095, USA,

    Jaclyn M. Winter & Yi Tang

  2. Yi Tang is also in the Department of Chemistry at the University of California, Los Angeles, California 90095, USA,

    Yi Tang

Authors
  1. Jaclyn M. Winter
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  2. Yi Tang
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Correspondence to Jaclyn M. Winter or Yi Tang.

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Winter, J., Tang, Y. Getting a handle on peptides. Nature Chem 6, 1037–1038 (2014). https://doi.org/10.1038/nchem.2117

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