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DNA modifications

Another stable base in DNA

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Oxidation of 5-methylcytosine has been proposed to mediate active and passive DNA demethylation. Tracking the history of DNA modifications has now provided the first solid evidence that 5-hydroxymethylcytosine is a stable epigenetic modification.

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Figure 1: Isotope labelling of cytosine derivatives provides an insight into the mechanism for the deposition and the stability of DNA modifications.

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Authors and Affiliations

  1. Pijus Brazauskas and Skirmantas Kriaucionis are in the Nuffield Department of Clinical Medicine, University of Oxford, Headington, Oxford OX3 7DQ, UK,

    Pijus Brazauskas & Skirmantas Kriaucionis

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  1. Pijus Brazauskas
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  2. Skirmantas Kriaucionis
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Correspondence to Skirmantas Kriaucionis.

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Brazauskas, P., Kriaucionis, S. Another stable base in DNA. Nature Chem 6, 1031–1033 (2014). https://doi.org/10.1038/nchem.2115

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