Bicyclic peptides that are cell-permeable and can inhibit an intracellular target have been developed. These peptides consist of two rings: one enables the peptide to pass through the membrane, the other can inhibit the target.
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Liskamp, R. Bicycling into cells. Nature Chem 6, 855–857 (2014). https://doi.org/10.1038/nchem.2073
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DOI: https://doi.org/10.1038/nchem.2073
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