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Prebiotic chemistry

Ribozyme takes its vitamins

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Selection of an RNA catalyst that can use the vitamin thiamin to catalyse a key metabolic decarboxylation reaction has broad implications for understanding the role of RNA in the early stages of chemical evolution.

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Figure 1: The reaction between the suicide substrate and thiamin requires a catalyst in order to proceed.

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Authors and Affiliations

  1. Cynthia J. Burrows is in the Department of Chemistry, University of Utah, Salt Lake City, Utah 84112, USA,

    Cynthia J. Burrows

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  1. Cynthia J. Burrows
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Correspondence to Cynthia J. Burrows.

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Burrows, C. Ribozyme takes its vitamins. Nature Chem 5, 900–901 (2013). https://doi.org/10.1038/nchem.1786

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