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Antibiotics

Blocking bacterial defences

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Electrochemical sensing of the function of cell-membrane proteins has led to the identification of inhibitors that could provide a new approach to the identification of antimicrobial drugs.

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Figure 1: Blocking the bacterial nanopore Wza.

References

  1. Payne, D. J., Gwynn, M. N., Holmes, D. J. & Pompliano, D. L. Nature Rev. Drug Discov. 6, 29–40 (2007).

    Article  CAS  Google Scholar 

  2. Roemer, T. & Boone, C. Nature Chem. Biol. 9, 222–231 (2013).

    Article  CAS  Google Scholar 

  3. Jankute, M., Grover, S., Rana, A. K. & Besra, G. S. Fut. Microbiol. 7, 129–147 (2012).

    Article  CAS  Google Scholar 

  4. Whitfield, C. Ann. Rev. Biochem. 75, 39–68 (2006).

    Article  CAS  Google Scholar 

  5. Neher, E. & Sakmann, B. Nature 260, 799–802 (1976).

    Article  CAS  Google Scholar 

  6. Branton, D. et al. Nature Biotechnol. 26, 1146–1153 (2008).

    Article  CAS  Google Scholar 

  7. Kong, L. et al. Nature Chem. 5, 651–659 10.1038/nchem.1695(2013).

    Article  CAS  Google Scholar 

  8. Dong, C. et al. Nature 444, 226–229 (2006).

    Article  CAS  Google Scholar 

  9. Banerjee, A. et al. Proc. Natl Acad. Sci. USA 107, 8165–8170 (2010).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Ellis O'Neill and Robert Field are in the Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK,

    Ellis C. O'Neill & Robert A. Field

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  1. Ellis C. O'Neill
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  2. Robert A. Field
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Correspondence to Robert A. Field.

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O'Neill, E., Field, R. Blocking bacterial defences. Nature Chem 5, 642–643 (2013). https://doi.org/10.1038/nchem.1718

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