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Natural products contain a range of chemical structures optimized for biological interactions. Fragmenting these compounds could help to combine this diversity with the broad coverage of chemical space offered by fragment-based drug discovery, and help to improve the efficiency with which screening hits can become successful drugs.

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Figure 1: Chemical space rises exponentially with molecular size.

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Authors and Affiliations

  1. Brian K. Shoichet is Department of Pharmaceutical Chemistry & California Institute for Quantitative Biosciences University of California, San Francisco, 1700 4th St., Byers Hall Room 508D, San Francisco, California 94158, USA,

    Brian K. Shoichet

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  1. Brian K. Shoichet
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Correspondence to Brian K. Shoichet.

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Shoichet, B. Nature's pieces. Nature Chem 5, 9–10 (2013). https://doi.org/10.1038/nchem.1537

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