Nucleic acid aptamers have been employed to shield small molecules so that one among many similar reactive functional groups can be modified. This provides access to new chemical entities with potentially interesting properties while avoiding the use of covalent protecting groups.
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Silverman, S. Shields for small molecules. Nature Chem 4, 774–775 (2012). https://doi.org/10.1038/nchem.1468
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DOI: https://doi.org/10.1038/nchem.1468
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