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Medicinal chemistry

Forcing an enemy into the open

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A series of highly active, simplified analogues of the natural product bryostatin have been prepared. They offer an improved approach for the activation of latent HIV that could, in combination with current state-of-the-art antiretroviral therapy, offer hope for eventual eradication of the infection.

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Figure 1: Properties and key steps in the synthesis of bryologs.

References

  1. UNAIDS World Aids Day Report 2011 (Joint United Nations Programme on HIV/AIDS, 2011); available via http://go.nature.com/AAF4pB

  2. Cohen, M. S. & Baden, L. R. N. Engl. J. Med. http://dx.doi.org/10.1056/NEJMe1207438 (2012).

  3. Rerks-Ngarm, S. et al. N. Engl. J. Med. 361, 2209–2220 (2009).

    Article  CAS  Google Scholar 

  4. Deeks, S. G. et al. Nature Rev. Immunol. 12, 607–614 (2012).

    Article  CAS  Google Scholar 

  5. DeChristopher, B. A. et al. Nature Chem. 4, 705–710 (2012).

    Article  CAS  Google Scholar 

  6. Margolis, D. M. Curr. Opin. HIV AIDS 6, 25–29 (2011).

    Article  Google Scholar 

  7. Siliciano, R. F. & Greene, W. C. Cold Spring Harb. Perspect. Med. 1, a007096 (2011).

    Article  Google Scholar 

  8. Gustafson, K. R. et al. J. Med. Chem. 35, 1978–1986 (1992).

    Article  CAS  Google Scholar 

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Author notes

  1. David M. Margolis is in the Department of Medicine, University of North Carolina Chapel Hill, Chapel Hill, North Carolina 27599, USA

  2. david_margolis@med.unc.edu

Authors and Affiliations

  1. Christian Melander is in the Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695, USA,

    Christian Melander & David M. Margolis

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  1. Christian Melander
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  2. David M. Margolis
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Correspondence to Christian Melander or David M. Margolis.

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Melander, C., Margolis, D. Forcing an enemy into the open. Nature Chem 4, 692–693 (2012). https://doi.org/10.1038/nchem.1444

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