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Supramolecular chemistry

A hydrophobic haven for base pairs

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Hydrogen-bonded dimers of one and two base-pair nucleotides can be stabilized inside the hydrophobic pocket provided by self-assembled molecular cages. The results could bring DNA-based computing a step closer to reality.

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Figure 1: Mono- and dinucleotide base pairs in water can be stabilized by encapsulation in self-assembled molecular cages.

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Thomas, J. A hydrophobic haven for base pairs. Nature Chem 1, 25–26 (2009). https://doi.org/10.1038/nchem.135

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