Hydrogen-bonded dimers of one and two base-pair nucleotides can be stabilized inside the hydrophobic pocket provided by self-assembled molecular cages. The results could bring DNA-based computing a step closer to reality.
References
Sawada, T. et al. Nature Chem. 1, 53–56 10.1038/nchem.100 (2009).
Fujita, M. et al. Acc. Chem. Res. 38, 371–380 (2005).
Yoshizawa, M. et al. J. Am. Chem. Soc. 122, 6311–6312 (2000).
Nakabayashi, K. et al. J. Am. Chem. Soc. 126, 16694–16695 (2004).
Yoshizawa, M. et al. Science 312, 251–254 (2006).
Ono, K. et al. Angew. Chem. Int. Ed. 46, 1803–1806 (2007).
Yoshizawa, M. et al. J. Am. Chem. Soc. 127, 13456–13457 (2005).
Thuong, T. N. & Hélène, C. Angew. Chem. Int. Ed. Engl. 32, 666–690 (1993).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Thomas, J. A hydrophobic haven for base pairs. Nature Chem 1, 25–26 (2009). https://doi.org/10.1038/nchem.135
Published:
Issue Date:
DOI: https://doi.org/10.1038/nchem.135
- Springer Nature Limited