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Cross-coupling

The final frontier

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Cross-coupling between a racemic secondary alkyl halide and an alkyl borane to produce an enantioenriched alkyl–alkyl product is one of the final substrate combinations to succumb to the synthetically powerful Suzuki–Miyaura methodology.

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Figure 1: γ- and δ-functionalization of carbonyl compounds.

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Authors and Affiliations

  1. Ben Glasspoole and Cathleen Crudden are in the Department of Chemistry at Queen's University, Chernoff Hall, 90 Bader Lane, Kingston, Ontario K7L 3N6, Canada,

    Ben W. Glasspoole & Cathleen M. Crudden

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  1. Ben W. Glasspoole
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  2. Cathleen M. Crudden
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Correspondence to Cathleen M. Crudden.

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Glasspoole, B., Crudden, C. The final frontier. Nature Chem 3, 912–913 (2011). https://doi.org/10.1038/nchem.1210

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