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F-actin organizes the nucleus

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After mitosis, the nucleus must be rebuilt and chromatin decondensed to permit interphase genomic functions, but decondensation mechanisms are poorly understood. Now, the traditional cytoskeletal protein actin is shown to form transient nuclear filaments that are required for chromatin decondensation and nuclear expansion at mitotic exit.

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Figure 1: Schematic model for the role of nuclear actin filaments in nuclear expansion and chromatin decondensation at mitotic exit.

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  1. Institute of Biotechnology, University of Helsinki, Finland Viikinkaari 5, Helsinki, Helsinki, 00014, Finland

    Henna M. Moore & Maria K. Vartiainen

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  1. Henna M. Moore
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  2. Maria K. Vartiainen
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Correspondence to Maria K. Vartiainen.

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Moore, H., Vartiainen, M. F-actin organizes the nucleus. Nat Cell Biol 19, 1386–1388 (2017). https://doi.org/10.1038/ncb3650

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