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Capturing endosomal vesicles at the Golgi

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Membrane trafficking specificity between distinct compartments ensures that cargo proteins and lipids are delivered to their target organelle. However, accurate recognition of cargo carriers by tethering factors on target membranes is poorly understood. TBC1D23 is now identified as an adaptor that links endosome-derived vesicles with golgins at the trans-Golgi.

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Figure 1: Ectopic golgin-BirA* fusion identifies binding partner.
Figure 2: TBC1D23 links golgins to the WASH complex on endosomal vesicles.

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Correspondence to Mary Munson.

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Fromme, J., Munson, M. Capturing endosomal vesicles at the Golgi. Nat Cell Biol 19, 1384–1386 (2017). https://doi.org/10.1038/ncb3649

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