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A fruitful liaison of ZSCAN10 and ROS on the road to rejuvenation

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Induced pluripotent stem cells derived from aged donors (A-iPSCs) usually show genomic instability that affects their utility and raises concerns about their safety. Now, a study highlights the importance of ZSCAN10-dependent recovery of glutathione–ROS homeostasis in counteracting the genomic defects in A-iPSCs.

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Figure 1: ZSCAN10 preserves genomic stability in iPSCs through the maintenance of ROS levels.

References

  1. Chandel, N. S., Jasper, H., Ho, T. T. & Passegue, E. Nat. Cell Biol. 18, 823–832 (2016).

    Article  CAS  Google Scholar 

  2. Neves, J., Sousa-Victor, P. & Jasper, H. Cell Stem Cell 20, 161–175 (2017).

    Article  CAS  Google Scholar 

  3. Soria-Valles, C. et al. Nat. Cell Biol. 17, 1004–1013 (2015).

    Article  CAS  Google Scholar 

  4. Kang, E. et al. Cell Stem Cell 18, 625–636 (2016).

    Article  CAS  Google Scholar 

  5. Lo Sardo, V. et al. Nat. Biotechnol. 35, 69–74 (2017).

    Article  CAS  Google Scholar 

  6. Guo, Z. et al. Science 330, 517–521 (2010).

    Article  CAS  Google Scholar 

  7. Franco, R. & Cidlowski, J. A. Cell Death Differ. 16, 1303–1314 (2009).

    Article  CAS  Google Scholar 

  8. Li, T. S. & Marban, E. Stem Cells 28, 1178–1185 (2010).

    Article  CAS  Google Scholar 

  9. Skamagki, M. et al. Nat. Cell Biol. 19, 1037–1048 (2017).

    Article  CAS  Google Scholar 

  10. Zhang, W. et al. Nucleic Acids Res. 34, 4780–4790 (2006).

    Article  CAS  Google Scholar 

  11. Yu, H. B., Kunarso, G., Hong, F. H. & Stanton, L. W. J. Biol. Chem. 284, 31327–31335 (2009).

    Article  CAS  Google Scholar 

  12. Kilpinen, H. et al. Nature 546, 370–375 (2017).

    Article  CAS  Google Scholar 

  13. Cheteh, E. H. et al. Cell Death Dis. 8, e2848 (2017).

    Article  CAS  Google Scholar 

  14. Zhou, G. et al. Cell Rep. 15, 919–925 (2016).

    Article  CAS  Google Scholar 

  15. Suda, T., Takubo, K. & Semenza, G. L. Cell Stem Cell 9, 298–310 (2011).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, Oviedo, 33006, Spain

    Clea Bárcena & Carlos López-Otín

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  1. Clea Bárcena
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  2. Carlos López-Otín
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Correspondence to Carlos López-Otín.

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The authors declare no competing financial interests.

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Bárcena, C., López-Otín, C. A fruitful liaison of ZSCAN10 and ROS on the road to rejuvenation. Nat Cell Biol 19, 1012–1013 (2017). https://doi.org/10.1038/ncb3602

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