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snoRNAs contribute to myeloid leukaemogenesis

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The mechanism of action of oncogenes in acute myeloid leukaemia is poorly understood. A study now shows that the fusion oncoprotein AML1-ETO regulates leukaemogenesis by increasing the expression of small nucleolar RNAs through post-transcriptional mechanisms, resulting in increased ribosomal RNA methylation, protein translation, and promotion of leukaemic-cell self-renewal and growth.

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Figure 1: AML1-ETO is a fusion oncoprotein frequently observed in AML patients.

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Authors and Affiliations

  1. Department of Pathology, NYU School of Medicine, New York, 10016, New York, USA

    Mona Khalaj & Christopher Y. Park

  2. Weill Graduate School of Medical Sciences, Cornell University, New York, 10065, New York, USA

    Mona Khalaj

  3. Memorial Sloan Kettering Cancer Center, New York, 10065, New York, USA

    Mona Khalaj

Authors
  1. Mona Khalaj
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  2. Christopher Y. Park
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Correspondence to Christopher Y. Park.

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Khalaj, M., Park, C. snoRNAs contribute to myeloid leukaemogenesis. Nat Cell Biol 19, 758–760 (2017). https://doi.org/10.1038/ncb3566

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