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Demystifying blood stem cell fates

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Determining the differentiation potential of stem and progenitor cells is essential for understanding their function, yet our ability to do so is limited by the restrictions of experimental assays. Based on single-cell functional and molecular profiling experiments, a new computational approach shows how lineage commitment may occur in human haematopoiesis.

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Figure 1: Single-cell data suggest an alternative model of human adult haematopoiesis.

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Authors and Affiliations

  1. Fiona K. Hamey and Berthold Göttgens are in the Department of Haematology, Wellcome Trust — Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom,

    Fiona K. Hamey & Berthold Göttgens

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  1. Fiona K. Hamey
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  2. Berthold Göttgens
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Correspondence to Berthold Göttgens.

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The authors declare no competing financial interests.

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Hamey, F., Göttgens, B. Demystifying blood stem cell fates. Nat Cell Biol 19, 261–263 (2017). https://doi.org/10.1038/ncb3494

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