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Pulling cells out of tumours

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Tumours are highly complex and contain multiple cell types. Cancer-associated fibroblasts are now shown to have a critical role in directly leading cancer cell invasion. This intercellular interaction relies on a mechanically active cadherin-based junction, and CAF-led invasion is demonstrated to require E-cadherin in the cancer cell.

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Figure 1: Fibroblasts lead cancer cell invasion via cadherin-mediated junctions.
Figure 2: Cadherin-dependent fibroblast-led cancer invasion.

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Correspondence to Andrew J. Ewald.

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Ewald, A. Pulling cells out of tumours. Nat Cell Biol 19, 147–149 (2017). https://doi.org/10.1038/ncb3484

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