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Inheritance of protection from osmotic stress

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Exposure of mother worms to mild osmotic stress induces gene expression changes in offspring that protect them from strong osmotic stress. Inheritance of protection is now shown to depend on altered insulin-like signalling in the maternal germline, which confers protection through increased expression of zygotic gpdh-2, a rate-limiting enzyme in glycerol biosynthesis.

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Figure 1: Adaptive and maternally inherited larval responses to osmotic stress.

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Authors and Affiliations

  1. Kiyomi R. Kaneshiro and Susan Strome are in the Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California 95064, USA,

    Kiyomi R. Kaneshiro & Susan Strome

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  1. Kiyomi R. Kaneshiro
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  2. Susan Strome
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Correspondence to Susan Strome.

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The authors declare no competing financial interests.

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Kaneshiro, K., Strome, S. Inheritance of protection from osmotic stress. Nat Cell Biol 19, 151–152 (2017). https://doi.org/10.1038/ncb3483

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