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Haematopoietic stem cells show their true colours

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Delineating the behaviour of haematopoietic stem cells (HSCs) in vivo has thus far proven challenging. Two studies in zebrafish and mouse models now track HSCs in vivo using fate mapping with multicolour approaches to provide further insights into clonal events that regulate blood development, HSC function and differentiation during homeostasis and stress conditions.

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Figure 1: Tracking clonal dynamics during homeostasis and stress.

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Authors and Affiliations

  1. Department of Pathology, Trista E. North is at the Beth Israel Deaconess Medical Center, Harvard Medical School, Harvard Stem Cell Institute, CLS 536, 3 Blackfan Circle, Boston, Massachusetts 02115, USA,

    Trista E. North

  2. Genetics and Gastroenterology Division, Wolfram Goessling is at the Brigham and Women's Hospital, Harvard Medical School, Harvard Stem Cell Institute, NRB 458, 77 Avenue Louis Pasteur, Boston, Massachusetts 02215, USA,

    Wolfram Goessling

Authors
  1. Trista E. North
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  2. Wolfram Goessling
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Correspondence to Trista E. North or Wolfram Goessling.

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North, T., Goessling, W. Haematopoietic stem cells show their true colours. Nat Cell Biol 19, 10–12 (2017). https://doi.org/10.1038/ncb3459

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