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Getting a grip on collective cell migration

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Many cell types in our body move in a collective manner, which requires individual cells to align their movements relative to that of their neighbours. A mechanism is now described in which cadherin-rich protrusions are extended from leading migrating cells and engulfed by follower cells to guide collective migration.

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Figure 1: The emergence of VE-cadherin fingers from the rear end of leader cells and their engulfment at the front end of the immediate follower cells guides the two-dimensional collective migration of HUVECs in vitro.

References

  1. Friedl, P. & Gilmour, D. Nat. Rev. Mol. Cell Biol. 10, 445–457 (2009).

    Article  CAS  PubMed  Google Scholar 

  2. Bianco, A. et al. Nature 448, 362–365 (2007).

    Article  CAS  PubMed  Google Scholar 

  3. Friedl, P., Locker, J., Sahai, E. & Segall, J. E. Nat. Cell Biol. 14, 777–783 (2012).

    Article  PubMed  Google Scholar 

  4. Haeger, A., Wolf, K., Zegers, M. M. & Friedl, P. Trends Cell Biol. 25, 556–566 (2015).

    Article  PubMed  Google Scholar 

  5. Das, T. et al. Nat. Cell Biol. 17, 276–287 (2015).

    Article  CAS  PubMed  Google Scholar 

  6. Hidalgo-Carcedo, C. et al. Nat. Cell Biol. 13, 49–58 (2011).

    Article  CAS  PubMed  Google Scholar 

  7. Reffay, M. et al. Nat. Cell Biol. 16, 217–223 (2014).

    Article  CAS  PubMed  Google Scholar 

  8. Tambe, D. T. et al. Nat. Mater. 10, 469–475 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Theveneau, E. et al. Nat. Cell Biol. 15, 763–772 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Wang, X. B., He, L., Wu, Y. I., Hahn, K. M. & Montell, D. J. Nat. Cell Biol. 12, 591–597 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Donà, E. et al. Nature 503, 285–289 (2013).

    Article  PubMed  Google Scholar 

  12. Hayer, A. et al. Nat. Cell Biol. 18, 1311–1323 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Delanoë-Ayari, H. et al. Phys. Rev. Lett. 93, 108102 (2004).

    Article  PubMed  Google Scholar 

  14. Machacek, M. et al. Nature 461, 99–103 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Wu, Y. I. et al. Nature 461, 104–108 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

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Correspondence to Tamal Das or Joachim P. Spatz.

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Das, T., Spatz, J. Getting a grip on collective cell migration. Nat Cell Biol 18, 1265–1267 (2016). https://doi.org/10.1038/ncb3447

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