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Chromosomes at loose ends

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Broken ends of a budding yeast chromosome exhibit increased mobility, presumably to facilitate repair by recombination. A new study reports that increased mobility reflects the untethering of the broken chromosome, triggered by a DNA damage response that phosphorylates the Cep3 kinetochore protein and weakens the association between the centromere and the spindle pole body.

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Figure 1: Models of DNA-damage-induced chromosome movement.

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Authors and Affiliations

  1. Yuko Nakajima and James E. Haber are in the Department of Biology and Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, Massachusetts, USA,

    Yuko Nakajima & James E. Haber

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  1. Yuko Nakajima
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  2. James E. Haber
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Correspondence to James E. Haber.

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The authors declare no competing financial interests.

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Nakajima, Y., Haber, J. Chromosomes at loose ends. Nat Cell Biol 18, 257–259 (2016). https://doi.org/10.1038/ncb3321

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