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Actin shapes the autophagosome

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Compared with most intracellular vesicles, the autophagosome is formed by an unusual event of vesicle budding involving an elusive sequence of membrane expansions that ends with a double membrane vesicle. It is now shown that actin polymerization inside the forming autophagosome is a driving force for the expansion and assembly of a functional autophagosome.

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Figure 1: Actin shapes autophagosome structures from inside the isolation membrane.

References

  1. Mi, N. et al. Cell Biol. 17, 1112–1123 (2015).

    CAS  Google Scholar 

  2. Chhabra, E. S. & Higgs, H. N. Nat. Cell Biol. 9, 1110–1121 (2007).

    Article  CAS  Google Scholar 

  3. Svitkina, T. M. & Borisy, G. G. J. Cell Biol. 145, 1009–1026 (1999).

    Article  CAS  Google Scholar 

  4. Kaksonen, M., Toret, C. P. & Drubin, D. G. Nat. Rev. Mol. Cell Biol. 7, 404–414 (2006).

    Article  CAS  Google Scholar 

  5. May, R. C., Caron, E., Hall, A. & Machesky, L. M. Nat. Cell Biol. 2, 246–248 (2000).

    Article  CAS  Google Scholar 

  6. Schafer, D. A., Jennings, P. B. & Cooper, J. A. J. Cell Biol. 135, 169–179 (1996).

    Article  CAS  Google Scholar 

  7. Aguilera, M. O., Berón, W. & Colombo, M. I. Autophagy 8, 1590–1603 (2012).

    Article  CAS  Google Scholar 

  8. Sawa-Makarska, J. et al. Nat. Cell Biol. 16, 425–433 (2014).

    Article  CAS  Google Scholar 

  9. Hayashi-Nishino, M. et al. Nat. Cell Biol. 11, 1433–1437 (2009).

    Article  CAS  Google Scholar 

  10. Yla-Anttila, P., Vihinen, H., Jokitalo, E. & Eskelinen, E. L. Autophagy 5, 1180–1185 (2009).

    Article  Google Scholar 

  11. Nath, S. et al. Nat. Cell Biol. 16, 415–424 (2014).

    Article  CAS  Google Scholar 

  12. Carlsson, S. R. & Simonsen, A. J. Cell Sci. 128, 193–205 (2015).

    Article  CAS  Google Scholar 

  13. Twig, G., Hyde, B. & Shirihai, O. S. Biochim. Biophys. Acta 1777, 1092–1097 (2008).

    Article  CAS  Google Scholar 

  14. Friedman, J. R. et al. Science 334, 358–362 (2011).

    Article  CAS  Google Scholar 

  15. Korobova, F., Ramabhadran, V. & Higgs, H. N. Science 339, 464–467 (2013).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Petter Holland and Anne Simonsen are in the Department of Molecular Medicine, Insititute of Basic Medical Sciences, University of Oslo, 0317 Oslo, Norway,

    Petter Holland & Anne Simonsen

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  1. Petter Holland
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  2. Anne Simonsen
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Correspondence to Anne Simonsen.

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The authors declare no competing financial interests.

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Holland, P., Simonsen, A. Actin shapes the autophagosome. Nat Cell Biol 17, 1094–1096 (2015). https://doi.org/10.1038/ncb3224

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