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How cells coordinate waste removal through their major proteolytic pathways

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The eukaryotic cell uses two complex machineries to degrade unwanted proteins. The first is the ubiquitin–proteasome system and the second is autophagy. A new study contributes to our understanding of how the two systems interconnect to coordinate protein degradation.

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Figure 1: The ubiquitin–proteasome pathway and autophagy are interconnected by shared degradation signals.

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Authors and Affiliations

  1. Sascha Martens and Andreas Bachmair are in the Department of Biochemistry and Cell Biology, Max F. Perutz Laboratories, Vienna BioCenter, University of Vienna, A-1030 Vienna, Austria,

    Sascha Martens & Andreas Bachmair

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  1. Sascha Martens
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  2. Andreas Bachmair
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Correspondence to Sascha Martens or Andreas Bachmair.

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The authors declare no competing financial interests.

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Martens, S., Bachmair, A. How cells coordinate waste removal through their major proteolytic pathways. Nat Cell Biol 17, 841–842 (2015). https://doi.org/10.1038/ncb3198

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