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Clarifying the role of condensin in shaping chromosomes

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A major controversy in the field of chromosome research has been whether condensin is required for achieving the highly compacted state of chromatin fibres in mitosis and meiosis. Through genetic experiments in mouse oocytes, condensin is now found to be indispensable for meiotic chromosome assembly by mediating chromosome compaction and disentanglement of sister chromatids and by conferring rigidity to chromosomes.

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Figure 1: Essential roles of condensin in shaping mitotic chromosomes.

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Authors and Affiliations

  1. Kota Nagasaka and Toru Hirota are in the Division of Experimental Pathology, Cancer Institute of the Japanese Foundation for Cancer Research (JFCR), Ariake 3-8-31, Koto-ku, Tokyo 135-8550, Japan,

    Kota Nagasaka & Toru Hirota

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  1. Kota Nagasaka
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  2. Toru Hirota
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Correspondence to Toru Hirota.

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The authors declare no competing financial interests.

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Nagasaka, K., Hirota, T. Clarifying the role of condensin in shaping chromosomes. Nat Cell Biol 17, 711–713 (2015). https://doi.org/10.1038/ncb3183

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