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Two paths to fat

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Excess caloric intake leads to both the growth of existing fat cells and the generation of new adipocytes. New findings show that PI3K–Akt2 signalling is involved in the differentiation of adult adipose precursor cells — a pathway not required for adipogenesis in the embryo.

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Figure 1: Alternative ways of accommodating additional fat.
Figure 2: Adipose stem cell signalling in embryos and adults.

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Authors and Affiliations

  1. Evan D. Rosen is in the Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA,

    Evan D. Rosen

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  1. Evan D. Rosen
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Correspondence to Evan D. Rosen.

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Rosen, E. Two paths to fat. Nat Cell Biol 17, 360–361 (2015). https://doi.org/10.1038/ncb3133

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