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Sugar modification inhibits autophagosome–lysosome fusion

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Autophagy is an intracellular degradation system that is mediated by orchestrated functions of membranes and proteins. A genetic screen in Caenorhabditis elegans revealed that O-linked N-acetylglucosamine modification of the SNARE protein SNAP-29 negatively regulates SNARE-dependent fusion between autophagosomes and lysosomes. This regulatory mechanism is conserved in mammals.

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Figure 1: Regulation of autophagosome–lysosome fusion.

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Authors and Affiliations

  1. Noboru Mizushima is in the Department of Biochemistry and Molecular Biology, Graduate School and Faculty of Medicine, The University of Tokyo, Tokyo 113-0033, Japan,

    Noboru Mizushima

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  1. Noboru Mizushima
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Correspondence to Noboru Mizushima.

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Mizushima, N. Sugar modification inhibits autophagosome–lysosome fusion. Nat Cell Biol 16, 1132–1133 (2014). https://doi.org/10.1038/ncb3078

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