Skip to main content
SpringerLink
Log in

Towards elucidating the tubulin code

  • News & Views
  • Published:

From Nature Cell Biology

View current issue Submit your manuscript

Genetically encoded and post-translationally generated variations of tubulin C-terminal tails give rise to extensive heterogeneity of the microtubule cytoskeleton. The generation of different tubulin variants in yeast now demonstrates how single amino-acid differences or post-translational modifications can modulate the behaviour of selected molecular motors.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Diversity of C-terminal tubulin tails.

References

  1. Mitchison, T. & Kirschner, M. Nature 312, 237–242 (1984).

    Article  CAS  PubMed  Google Scholar 

  2. Schliwa, M. & Woehlke, G. Nature 422, 759–765 (2003).

    Article  CAS  PubMed  Google Scholar 

  3. Luduena, R. F. Int. Rev. Cytol. 178, 207–275 (1998).

    Article  CAS  PubMed  Google Scholar 

  4. Janke, C. & Bulinski, J. C. Nat. Rev. Mol. Cell Biol. 12, 773–786 (2011).

    Article  CAS  PubMed  Google Scholar 

  5. Amos, L. A. Curr. Opin. Struct. Biol. 10, 236–241 (2000).

    Article  CAS  PubMed  Google Scholar 

  6. Lacroix, B. et al. J. Cell Biol. 189, 945–954 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Bieling, P. et al. J. Cell Biol. 183, 1223–1233 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Sirajuddin, M., Rice, L. M. & Vale, R. D. Nat. Cell Biol. 16, 335–344 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Verhey, K. J. & Gaertig, J. Cell Cycle 6, 2152–2160 (2007).

    Article  CAS  PubMed  Google Scholar 

  10. Ayaz, P., Ye, X., Huddleston, P., Brautigam, C. A. & Rice, L. M. Science 337, 857–860 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Hallak, M. E., Rodriguez, J. A., Barra, H. S. & Caputto, R. FEBS Lett. 73, 147–150 (1977).

    Article  CAS  PubMed  Google Scholar 

  12. Peris, L. et al. J. Cell Biol. 185, 1159–1166 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Eddé, B. et al. Science 247, 83–85 (1990).

    Article  PubMed  Google Scholar 

  14. Alexander, J. E. et al. Proc. Natl Acad. Sci. USA 88, 4685–4689 (1991).

    Article  CAS  PubMed  Google Scholar 

  15. Rüdiger, M., Plessman, U., Kloppel, K. D., Wehland, J. & Weber, K. FEBS Lett. 308, 101–105 (1992).

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Signalling, Annemarie Wehenkel and Carsten Janke are at Institut Curie, Neurobiology and Cancer, CNRS UMR 3306/INSERM U1005, Bat 110, Centre Universitaire, 91405 Orsay Cedex, France,

    Annemarie Wehenkel & Carsten Janke

Authors
  1. Annemarie Wehenkel
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Carsten Janke
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Annemarie Wehenkel or Carsten Janke.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wehenkel, A., Janke, C. Towards elucidating the tubulin code. Nat Cell Biol 16, 303–305 (2014). https://doi.org/10.1038/ncb2938

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncb2938

  • Springer Nature Limited

This article is cited by

Search

Navigation