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A microRNA-operated switch of asymmetric-to-symmetric cancer stem cell divisions

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Defective asymmetric cell divisions of stem and progenitor cells are associated with tumorigenesis by a largely unknown mechanism. A signalling axis involving Snail, microRNA-146a and Numb is now shown to regulate the switch between symmetric and asymmetric cell division in colorectal cancer stem cells.

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Figure 1: Cell division modes used by cancer stem cells and their regulation in colorectal cancer.

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Authors and Affiliations

  1. Robin G. Lerner and Claudia Petritsch are in the Department of Neurological Surgery, Brain Tumor Research Center, Helen Diller Comprehensive Cancer Center, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, California, USA,

    Robin G. Lerner & Claudia Petritsch

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  1. Robin G. Lerner
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  2. Claudia Petritsch
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Correspondence to Claudia Petritsch.

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The authors declare no competing financial interests.

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Lerner, R., Petritsch, C. A microRNA-operated switch of asymmetric-to-symmetric cancer stem cell divisions. Nat Cell Biol 16, 212–214 (2014). https://doi.org/10.1038/ncb2924

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