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Centriole biogenesis in multiciliated cells

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Centrioles duplicate only once per cell cycle in proliferating cells, whereas in multiciliated cells, hundreds of centrioles form almost simultaneously. The molecular control mechanisms that govern centriole amplification in multiciliated cells are largely unknown. Two studies highlight Deup1 and CCDC78 as key players in this process.

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Figure 1: Multiple types of centriole-dependent centriole duplication or amplification in human cycling cells.
Figure 2: Multiple pathways of ciliogenesis.

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Authors and Affiliations

  1. Tang K. Tang is at the Institute of Biomedical Sciences, Academia Sinica, Taipei, 11529, Taiwan,

    Tang K. Tang

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  1. Tang K. Tang
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Tang, T. Centriole biogenesis in multiciliated cells. Nat Cell Biol 15, 1400–1402 (2013). https://doi.org/10.1038/ncb2892

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