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Hedgehog threads to spread

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In vivo time-lapse imaging and functional tests bring fresh evidence that the morphogen Hedgehog is conveyed to target cells via long filopodia extensions, dubbed cytonemes. This study provides the tools and conceptual framework to understand how cytonemes form and carry morphogens.

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Figure 1: Cytonemes and the questions they raise.

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Authors and Affiliations

  1. James Briscoe and Jean-Paul Vincent are at the MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK,

    James Briscoe & Jean-Paul Vincent

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  1. James Briscoe
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  2. Jean-Paul Vincent
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Correspondence to James Briscoe or Jean-Paul Vincent.

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The authors declare no competing financial interests.

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Briscoe, J., Vincent, JP. Hedgehog threads to spread. Nat Cell Biol 15, 1265–1267 (2013). https://doi.org/10.1038/ncb2878

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