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Crosstalk between mTOR complexes

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The mTOR protein kinase controls anabolic processes as part of mTOR complexes 1 and 2 (mTORC1 and mTORC2). The two complexes are now shown to be involved in a negative feedback regulatory mechanism, in which mTORC1 stimulation inactivates mTORC2 through the inhibitory phosphorylation of the mTORC2 component Sin1.

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Figure 1: Crosstalk between the two mTOR complexes.
Figure 2: Roles of Akt and S6K in crosstalk between mTOR complexes.

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Authors and Affiliations

  1. Jianling Xie and Christopher G. Proud are at the Centre for Biological Sciences, Life Sciences Building (B85), University of Southampton, Southampton SO17 1BJ, UK,

    Jianling Xie & Christopher G. Proud

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  1. Jianling Xie
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  2. Christopher G. Proud
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Correspondence to Christopher G. Proud.

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The authors declare no competing financial interests.

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Xie, J., Proud, C. Crosstalk between mTOR complexes. Nat Cell Biol 15, 1263–1265 (2013). https://doi.org/10.1038/ncb2877

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