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Linking HSCs to their youth

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An Erratum to this article was published on 02 September 2013

This article has been updated

Fetal haematopoietic stem cells (HSCs) self-renew extensively to build the blood system from scratch. The protein Lin28b negatively regulates the microRNA let-7 to keep levels of its target Hmga2 high, hence conferring high self-renewal potential to fetal HSCs. This regulatory circuit can be experimentally modulated to boost the lower self-renewal activity of quiescent adult HSCs.

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Figure 1: Fetal and adult HSCs have distinct programs suited to their developmental stage.
Figure 2: Modular regulation of the fetal HSC program.

Change history

  • 02 August 2013

    In the version of this News and Views originally published, there was an error in Fig. 1: the blue cell on the right should have been labelled ‘Adult HSC’, not ‘Fetal HSC’. This has been corrected in the HTML and PDF versions.

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Authors and Affiliations

  1. Department of Medicine, Division of Hematology/Oncology, Eric M. Pietras and Emmanuelle Passegué are at the The Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California San Francisco, 35 Medical Center Way, RMB 1017, San Francisco, California, USA,

    Eric M. Pietras & Emmanuelle Passegué

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  1. Eric M. Pietras
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  2. Emmanuelle Passegué
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Correspondence to Emmanuelle Passegué.

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The authors declare no competing financial interests.

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Pietras, E., Passegué, E. Linking HSCs to their youth. Nat Cell Biol 15, 885–887 (2013). https://doi.org/10.1038/ncb2817

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