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MyomiRs-133a/b turn off the heat

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Brown adipose tissue is intensively researched owing to its role in regulating energy and glucose homeostasis. Its differentiation is controlled through adrenergic-dependent regulation of the transcriptional co-regulator Prdm16. Adrenergic stimulation inhibits expression of miR-133a/b in a Mef2c-dependent manner to abrogate post-transcriptional silencing of Prdm16.

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Figure 1: miR-133a/b activity in the control of brown adipose tissue function.

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Authors and Affiliations

  1. Jan-Wilhelm Kornfeld and Jens C. Brüning are at the Max Planck Institute for Neurological Research, Gleueler Street 50a, 50931 Köln, Germany, and the Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne, Zülpicher Street 47a, 50674 Köln, Germany,

    Jan-Wilhelm Kornfeld & Jens C. Brüning

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  1. Jan-Wilhelm Kornfeld
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  2. Jens C. Brüning
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Correspondence to Jens C. Brüning.

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The authors declare no competing financial interests.

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Kornfeld, JW., Brüning, J. MyomiRs-133a/b turn off the heat. Nat Cell Biol 14, 1248–1249 (2012). https://doi.org/10.1038/ncb2642

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