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Profilin phosphorylation as a VEGFR effector in angiogenesis

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Vascular endothelial growth factor (VEGF) signalling induces embryonic vascular development and angiogenesis in adult tissues. Direct phosphorylation of the actin-binding protein profilin by VEGF receptors is now shown to increase its affinity for actin, and to be essential for adult but not embryonic arteriogenesis.

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Figure 1: Profilin in VEGF signalling.

References

  1. Koch, S., Tugues, S., Li, X., Gualandi, L. & Claesson-Welsh, L. Biochem. J. 437, 169–183 (2011).

    Article  CAS  Google Scholar 

  2. Carmeliet, P. & Jain, R. K. Nature 473, 298–307 (2011).

    Article  CAS  Google Scholar 

  3. Simons, M. Physiology 27, 213–222 (2012).

    Article  CAS  Google Scholar 

  4. Fan, Y. et al. Nat. Cell Biol. 14, 1046–1056 (2012).

    Article  CAS  Google Scholar 

  5. Witke, W. Trends Cell Biol. 14, 461–469 (2004).

    Article  CAS  Google Scholar 

  6. Birbach, A. Bioessays 30, 994–1002 (2008).

    Article  CAS  Google Scholar 

  7. Aspenstrom, P. Biochim. Biophys. Acta 1803, 174–182 (2010).

    Article  Google Scholar 

  8. Swaney, K. F., Huang, C. H. & Devreotes, P. N. Annu. Rev. Biophys. 39, 265–289 (2010).

    Article  CAS  Google Scholar 

  9. Ding, Z., Lambrechts, A., Parepally, M. & Roy, P. J. Cell Sci. 119, 4127–4137 (2006).

    Article  CAS  Google Scholar 

  10. Eilken, H. M. & Adams, R. H. Curr. Opin. Cell Biol. 22, 617–625 (2010).

    Article  CAS  Google Scholar 

  11. Cao, G. et al. Am. J. Pathol. 175, 903–915 (2009).

    Article  CAS  Google Scholar 

  12. Chen, Z., Rubin, J. & Tzima, E. Circ. Res. 107, 1355–1363 (2010).

    Article  CAS  Google Scholar 

  13. Fantin, A. et al. Blood 116, 829–840 (2010).

    Article  CAS  Google Scholar 

  14. Takeda, Y. et al. Nature 479, 122–126 (2011).

    Article  CAS  Google Scholar 

  15. Jockusch, B. M., Murk, K. & Rothkegel, M. Rev. Physiol. Biochem. Pharmacol. 159, 131–149 (2007).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Internal Medicine and Department of Cell Biology, Michael Simons and Martin A. Schwartz are in the Yale Cardiovascular Research Center, Section Of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA,

    Michael Simons & Martin A. Schwartz

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  1. Michael Simons
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  2. Martin A. Schwartz
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Correspondence to Michael Simons or Martin A. Schwartz.

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Simons, M., Schwartz, M. Profilin phosphorylation as a VEGFR effector in angiogenesis. Nat Cell Biol 14, 985–987 (2012). https://doi.org/10.1038/ncb2596

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