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Unanchoring integrins in focal adhesions

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Focal adhesions are large structures through which integrins and scaffold proteins link the actin cytoskeleton to the extracellular matrix. A detailed analysis of integrin dynamics now indicates that focal-adhesion-associated integrins constantly switch between active and immobilized, and unbound and free-diffusing states, with different fibronectin-binding integrin heterodimers showing distinct focal-adhesion dynamics.

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Figure 1: Integrin dynamics outside and inside focal adhesions.

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Authors and Affiliations

  1. Johanna Ivaska is in the Turku Centre for Biotechnology, University of Turku, and VTT Technical Research Centre of Finland, Turku 20520, Finland,

    Johanna Ivaska

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  1. Johanna Ivaska
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Correspondence to Johanna Ivaska.

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Ivaska, J. Unanchoring integrins in focal adhesions. Nat Cell Biol 14, 981–983 (2012). https://doi.org/10.1038/ncb2592

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