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FOXOphagy path to inducing stress resistance and cell survival

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Nutrient deprivation and other stress stimuli elicit metabolic changes (such as the induction of autophagy and activation of FOXO transcription factors) that help an organism adapt to stressful conditions. A link between these stress response pathways is revealed by the finding that FOXO3 upregulates the expression of glutamine synthetase to promote glutamine accumulation, inhibit mTOR signalling and promote autophagy.

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Figure 1: FOXO regulates the induction of autophagy by promoting expression of glutamine synthetase.

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Authors and Affiliations

  1. Marco Sandri is in the Department of Biomedical Sciences, and the Department of Medicine, University of Padova, 35121 Padova, Italy, the Dulbecco Telethon Institute, Venetian Institute of Molecular Medicine, 35129 Padova, Italy, the Institute of Neuroscience, Consiglio Nazionale delle Ricerche, 35121 Padova, Italy, McGill University, Montreal, H3A 1A1, Canada,

    Marco Sandri

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  1. Marco Sandri
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Correspondence to Marco Sandri.

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Sandri, M. FOXOphagy path to inducing stress resistance and cell survival. Nat Cell Biol 14, 786–788 (2012). https://doi.org/10.1038/ncb2550

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