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Fishing for clathrin-coated pit nucleators

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The membrane-curvature-inducing protein Fcho was proposed to be part of a ubiquitous nucleation mechanism for clathrin-coated pits. However, studies in developing zebrafish embryos now indicate a role for Fcho as a receptor-specific adaptor in bone morphogenetic protein (BMP) signalling, rather than a global coated-pit nucleator.

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Figure 1: Models of coated-pit nucleation.

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  1. Christien J. Merrifield is at the Centre National de la Recherche Scientifique UPR 3082, Laboratoire d'Enzymologie et de Biochimie Structurales, Gif-sur-Yvette Cedex, France,

    Christien J. Merrifield

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  1. Christien J. Merrifield
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Correspondence to Christien J. Merrifield.

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Merrifield, C. Fishing for clathrin-coated pit nucleators. Nat Cell Biol 14, 452–454 (2012). https://doi.org/10.1038/ncb2497

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