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Good neighbours in the tumour stroma reduce oxidative stress

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Tumour cells undergo oncogene-regulated metabolic reprogramming that maximizes survival and growth. However, little is known about metabolic interactions between tumour cells and their non-malignant neighbours in the stroma. Bone-marrow-derived stromal cells are now shown to provide cysteine, an essential nutrient that enables leukaemia cells to resist oxidative stress.

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Figure 1: Metabolic interactions between CLL tumour cells and neighbouring bone marrow-derived stromal cells promote tumour cell survival.

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  1. Ralph J. DeBerardinis is at the University of Texas, Southwestern Medical Center, Children's Research Institute, 5323 Harry Hines Boulevard, Dallas, Texas 75390-8502, USA,

    Ralph J. DeBerardinis

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  1. Ralph J. DeBerardinis
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Correspondence to Ralph J. DeBerardinis.

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DeBerardinis, R. Good neighbours in the tumour stroma reduce oxidative stress. Nat Cell Biol 14, 235–236 (2012). https://doi.org/10.1038/ncb2449

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