Skip to main content
SpringerLink
Log in

A new cap for kinetochore fibre minus ends

  • News & Views
  • Published:

From Nature Cell Biology

View current issue Submit your manuscript

In mitotic spindles, each sister chromatid is directly attached to a spindle pole through microtubule bundles known as kinetochore fibres. Microspherule protein 1 (MCRS1) is now shown to support spindle assembly by localizing to the minus ends of kinetochore fibres and protecting them from depolymerization.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: MCRS1 has multiple functions in interphase and mitosis.

References

  1. Walczak, C. E. & Heald, R. Int. Rev. Cytol. 265, 111–158 (2008).

    Article  CAS  Google Scholar 

  2. Cheeseman, I. M. & Desai, A. Nat. Rev. Mol. Cell Bio. 9, 33–46 (2008).

    Article  CAS  Google Scholar 

  3. Meunier, S. & Vernos, I. Nat. Cell Biol. http://dx.doi.org/10.1038/ncb2372 (2011).

  4. Shimono, K., Shimono, Y., Shimokata, K., Ishiguro, N., & Takahashi, M. J. Biol. Chem. 280, 39436–39447 (2005).

    Article  CAS  Google Scholar 

  5. Andersen, D. S. et al. Mol. Cell Biol. 30, 4744–4755 (2010).

    Article  CAS  Google Scholar 

  6. Song, H. et al. Biochem. Biophys. Res. Commun. 316, 1116–1123 (2004).

    Article  CAS  Google Scholar 

  7. Hirohashi, Y. et al. Oncogene 25, 4937–4946 (2006).

    Article  CAS  Google Scholar 

  8. Tulu U. S., Fagerstrom, C., Ferenz, N. P. & Wadsworth, P. Curr. Biol. 16, 536–541 (2006).

    Article  CAS  Google Scholar 

  9. Mitchison, T. J. J. Cell Biol. 109, 637–652 (1989).

    Article  CAS  Google Scholar 

  10. Waters, J. C., Mitchison, T. J., Rieder, C. L., & Salmon, E. D. Mol. Biol. Cell 7, 1547–1558 (1996).

    Article  CAS  Google Scholar 

  11. DeLuca, J. G. et al. Cell 127, 969–982 (2006).

    Article  CAS  Google Scholar 

  12. Ohi, R., Burbank, K., Liu, Q. & Mitchison, T. J. (2007) Curr. Biol. 17, 953–959 (2007).

    Article  CAS  Google Scholar 

  13. Goodwin, S. S. & Vale, R. D. Cell 143, 263–274 (2010).

    Article  CAS  Google Scholar 

  14. Kalab, P. & Heald, R. J. Cell Sci. 121, 1577–1586 (2008).

    Article  CAS  Google Scholar 

  15. Gruss, O. J. et al. Cell 104, 83–93 (2001).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Sabine Petry and Ronald D. Vale are at the Howard Hughes Medical Institute and Department of Cellular and Molecular Pharmacology, University of California, 600 16th Street, San Francisco, California 94158, USA,

    Sabine Petry & Ronald D. Vale

Authors
  1. Sabine Petry
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ronald D. Vale
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ronald D. Vale.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Petry, S., Vale, R. A new cap for kinetochore fibre minus ends. Nat Cell Biol 13, 1389–1391 (2011). https://doi.org/10.1038/ncb2387

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncb2387

  • Springer Nature Limited

This article is cited by

Search

Navigation