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Tagging the dead: a bridging factor for Caenorhabditis elegans phagocyte receptors

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Recognition of apoptotic cells by phagocytic cells in Caenorhabditis elegans has been something of a mystery. A secreted transthyretin-like protein, TTR-52, has been identified as a bridging molecule between apoptotic cells and CED-1 on the phagocytic cells that engulf them.

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Figure 1: TTR-52 is a bridging molecule that mediates the recognition of phosphatidylserine by the CED-1 phagocytic receptor in C. elegans.

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Authors and Affiliations

  1. Rachael Rutkowski and Anton Gartner are in the Wellcome Trust Centre for Gene Regulation and Expression, University of Dundee, Dundee DD1 5EH, UK. r.j.rutkowski@dundee.ac.uk,

    Rachael Rutkowski & Anton Gartner

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  1. Rachael Rutkowski
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  2. Anton Gartner
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The authors declare no competing financial interests.

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Rutkowski, R., Gartner, A. Tagging the dead: a bridging factor for Caenorhabditis elegans phagocyte receptors. Nat Cell Biol 12, 638–640 (2010). https://doi.org/10.1038/ncb2077

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