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Dynein at odd angles?

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Cytoplasmic dynein drives vesicular transport from the periphery to the cell body of neurons. Missense mutations in the dynein tail domain cause neurodegenerative disease in mouse models. New data on the effect of one such dynein mutation provide insight into the intramolecular communication and flexible stepping of this essential cellular motor.

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Figure 1: Differential stepping of wild-type and dynein from Loa-mutant mice.

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Authors and Affiliations

  1. Jacob E. Lazarus and Erika L. F. Holzbaur are in the Department of Physiology and the Pennsylvania Muscle Institute, Adam G. Hendricks, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. holzbaur@mail.med.upenn.edu,

    Adam G. Hendricks, Jacob E. Lazarus & Erika L. F. Holzbaur

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  1. Adam G. Hendricks
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  2. Jacob E. Lazarus
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  3. Erika L. F. Holzbaur
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The authors declare no competing financial interests.

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Hendricks, A., Lazarus, J. & Holzbaur, E. Dynein at odd angles?. Nat Cell Biol 12, 1126–1128 (2010). https://doi.org/10.1038/ncb1210-1126

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