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Kinesin: walking or limping?

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Some kinesin motors can move along a microtubule for many hundred steps without dissociating. These motors are dimers, but precisely how the two motor domains are coordinated during stepping is still the subject of debate. A novel experimental approach offers new insights.

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Figure 1: Models for kinesin stepping.

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Schliwa, M. Kinesin: walking or limping?. Nat Cell Biol 5, 1043–1044 (2003). https://doi.org/10.1038/ncb1203-1043

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