Skip to main content
Log in

Bad hair days for mouse PCP mutants

  • News & Views
  • Published:

From Nature Cell Biology

View current issue Submit your manuscript

Mammalian hairs have characteristic patterns of orientation, with a predominantly rostral to caudal direction, occasional swirls and a high level of local correlation between hairs. A detailed new study demonstrates that the polarity of hairs derives from an underlying planar polarity of the basal epidermal cells from which hair follicles arise.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Figure 1: PCP in the Drosophila wing and eye, and the mammalian vestibular epithelium.
Figure 2: PCP in mammalian hair germs.

References

  1. Devenport, D. & Fuchs, E. Nature Cell Biol. 10, 1257–1268 (2008).

    Article  CAS  PubMed  Google Scholar 

  2. Zallen, J. A. Cell 129, 1051–1063 (2007).

    Article  CAS  PubMed  Google Scholar 

  3. Vinson, C. R., Conover, S. & Adler, P. N. Nature 338, 263–264 (1989).

    Article  CAS  PubMed  Google Scholar 

  4. Taylor, J., Abramova, N., Charlton, J. & Adler, P. N. Genetics 150, 199–210 (1998).

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Usui, T. et al. Cell 98, 585–595 (1999).

    Article  CAS  PubMed  Google Scholar 

  6. Amonlirdviman, K. et al. Science 307, 423–426 (2005).

    Article  CAS  PubMed  Google Scholar 

  7. Ma, D., Yang, C. H., McNeill, H., Simon, M. A. & Axelrod, J. D. Nature 421, 543–547 (2003).

    Article  CAS  PubMed  Google Scholar 

  8. Casal, J., Lawrence, P. A. & Struhl, G. Development 133, 4561–4572 (2006).

    Article  CAS  PubMed  Google Scholar 

  9. Wang, Y. & Nathans, J. Development 134, 647–658 (2007).

    Article  CAS  PubMed  Google Scholar 

  10. Simons, M. & Mlodzik, M. Annu. Rev. Genet. (2008).

  11. Guo, N., Hawkins, C. & Nathans, J. Proc. Natl Acad. Sci. USA 101, 9277–9281 (2004).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Chen, W. S. et al. Cell 133, 1093–1105 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Cooper, M. T. & Bray, S. J. Nature 397, 526–530 (1999).

    Article  CAS  PubMed  Google Scholar 

  14. Fanto, M. & Mlodzik, M. Nature 397, 523–526 (1999).

    Article  CAS  PubMed  Google Scholar 

  15. Wang, Y., Badea, T. & Nathans, J. Proc. Natl Acad. Sci. USA 103, 19800–19805 (2006).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Axelrod, J. Bad hair days for mouse PCP mutants. Nat Cell Biol 10, 1251–1253 (2008). https://doi.org/10.1038/ncb1108-1251

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncb1108-1251

  • Springer Nature Limited

Navigation