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UCPs — unlikely calcium porters

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Figure 1: Ca2+ uptake by liver and heart mitochondria; effect of UCP inhibitors.
Figure 2: Ca2+ uptake in SkM mitochondria from wild-type (WT) and Ucp3−/− mice, plus liver and kidney mitochondria from WT and Ucp2−/− mice.

References

  1. Kirichok, Y., Krapivinsky, G. & Clapham D. E . Nature. 427, 360–364 (2004).

    Article  CAS  PubMed  Google Scholar 

  2. Trenker, M., Malli, R., Fertschai, I., Levak-Frank, S. & Graier, W. F. Nature Cell Biol. 9, 445–452 (2007).

    Article  CAS  PubMed  Google Scholar 

  3. Graier, W. F., Frieden, M., & Malli, R. Pflugers Arch. 455, 375–396 (2007).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Gunter, T. E., Buntinas, L., Sparagna, G., Eliseev, R. & Gunter, K. Cell Calcium. 28, 285–296 (2000).

    Article  CAS  PubMed  Google Scholar 

  5. Stuart, J. A., Harper, J. A., Brindle, K. M., Jekabsons, M. B. & Brand, M. D. Biochem. J. 356, 779–789 (2001).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Wingrove, D. E. & Gunter, T. E. J. Biol. Chem. 261, 15159–15165 (1986).

    CAS  PubMed  Google Scholar 

  7. Gunter, T. E. & Pfeiffer, D. R. Am. J. Physiol. 258, C755–C786 (1990).

    Article  CAS  PubMed  Google Scholar 

  8. Zazueta, C., Sosa-Torres, M. E., Correa, F. & Garza-Ortiz, A. J. Bioenerg. Biomembr. 31, 551–557 (1999).

    Article  CAS  PubMed  Google Scholar 

  9. Schwerzmann, K., Cruz-Orive, L. M., Eggman, R., Sänger, A., & Weibel, E. R. J. Cell Biol. 102, 97–103 (1986).

    Article  CAS  PubMed  Google Scholar 

  10. Brookes, P. S., Salinas, E. P., Darley-Usmar, K., Eiserich, J. P., Freeman, B. A., Darley-Usmar, V. M. & Anderson, P. G. J. Biol. Chem. 275, 20474–20479 (2000).

    Article  CAS  PubMed  Google Scholar 

  11. McLeod, C. J., Aziz, A., Hoyt, R. F. Jr., McCoy, J. P. Jr. & Sack, M. N. J. Biol. Chem. 280, 33470–33476 (2005).

    Article  CAS  PubMed  Google Scholar 

  12. Echtay, K. S., Roussel, D., St-Pierre, J., Jekabsons, M. B., Cadenas, S., Stuart, J. A., Harper, J. A., Roebuck, S. J., Morrison, A., Pickering, S., Clapham, J. C. & Brand, M. D. Nature 415, 96–99 (2002).

    Article  CAS  Google Scholar 

  13. Zhang, C. Y., Parton, L. E., Ye, C. P., Krauss, S., Shen, R., Lin, C. T., Porco, J. A. Jr. & Lowell .B. B. Cell Metab. 3, 417–427 (2006).

    Article  CAS  PubMed  Google Scholar 

  14. Gong, D. W., Monemdjou, S., Gavrilova, O., Leon, L. R., Marcus-Samuels, B., Chou, C. J., Everett, C., Kozak, L. P., Li, C., Deng, C., Harper, M. E. & Reitman, M. L. J. Biol. Chem. 275, 16251–16257 (2000).

    Article  CAS  PubMed  Google Scholar 

  15. Parker, N., Affourtit, C., Vidal-Puig, A. J. & Brand, M. D. Biochem. J. 412, 131–139 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

P.S.B. is funded by the US National Institutes of Health (RO1-HL071158). M.D.B. is supported by the Medical Research Council and the Wellcome Trust (065326/Z/01/Z and 066750/B/01/Z). We thank Mary-Ellen Harper (University of Ottawa, Canada) for Ucp3−/− mice, Brad Lowell (Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA) for Ucp2−/− mice, and Sergiy Nadtochiy (University of Rochester) for technical assistance.

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Authors and Affiliations

  1. Department of Anesthesiology, University of Rochester Medical Center, Rochester, NY, USA

    Paul S. Brookes

  2. MRC Dunn Human Nutrition Unit, Cambridge, UK

    Nadeene Parker, Julie A. Buckingham & Martin D. Brand

  3. Department of Clinical Biochemistry, Institute of Metabolic Science, University of Cambridge, UK

    Antonio Vidal-Puig

  4. Department of Biochemistry, Bristol University, UK

    Andrew P. Halestrap

  5. Department of Biochemistry & Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA

    Thomas E. Gunter

  6. Buck Institute for Age Research, Novato, CA, USA

    David G. Nicholls & Martin D. Brand

  7. Dipartimento di Scienze Biomediche Sperimentali, Università degli Studi di Padova, Padova, Italy

    Paolo Bernardi

  8. Department of Pharmaceutical and Biomedical Sciences, Center for Cell Death Injury and Regeneration, Medical University of South Carolina, Charleston, SC, USA

    John J. Lemasters

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Brookes, P., Parker, N., Buckingham, J. et al. UCPs — unlikely calcium porters. Nat Cell Biol 10, 1235–1237 (2008). https://doi.org/10.1038/ncb1108-1235

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