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How size is controlled: from Hippos to Yorkies

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How do developing organs sense and limit their size? The recently discovered Hippo pathway might have a critical role in controlling organ size and homeostasis in many organisms from Drosophila to mammals.

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Figure 1: The conserved Hippo kinase cascade.

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Authors and Affiliations

  1. Laura A. Buttitta and Bruce A. Edgar are at the Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. bedgar@fhcrc.org,

    Laura A. Buttitta & Bruce A. Edgar

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  1. Laura A. Buttitta
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  2. Bruce A. Edgar
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Buttitta, L., Edgar, B. How size is controlled: from Hippos to Yorkies. Nat Cell Biol 9, 1225–1227 (2007). https://doi.org/10.1038/ncb1107-1225

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