Skip to main content
SpringerLink
Log in

SePARating polarity and proliferation in ErbB2 oncogenesis

  • News & Views
  • Published:

From Nature Cell Biology

View current issue Submit your manuscript

Loss of tissue organization, including disruption of epithelial polarity, is a feature of many carcinomas. Activation of the oncogenic receptor tyrosine kinase, ErbB2, induces alterations in epithelial architecture, but the mechanisms underlying this effect are poorly understood. New data suggests that the polarity proteins, Par6 and atypical PKC, may affect epithelial polarity and cell survival through interactions with an ErbB2 receptor complex.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Effects of ErbB2 activation in MCF-10A acinar structures.
Figure 2: Schematic representation of a model for ErbB2-induced oncogenesis.

References

  1. Aranda, V. et al. Nature Cell Biol. 8, 1235–1245 (2006).

    Article  CAS  Google Scholar 

  2. Gibson, M.C. & Perrimon, N. Curr. Opin. Cell Biol. 15, 747–752 (2003).

    Article  CAS  Google Scholar 

  3. Bilder, D., Li, M. & Perrimon, N. Science 289, 113–116 (2000).

    Article  CAS  Google Scholar 

  4. Kiyono, T. et al. Proc. Natl Acad. Sci. USA 94, 11612–11616 (1997).

    Article  CAS  Google Scholar 

  5. Lee, S.S., Weiss, R.S. & Javier, R.T. Proc. Natl Acad. Sci. USA 94, 6670–6675 (1997).

    Article  CAS  Google Scholar 

  6. Nakagawa, S. & Huibregtse, J.M. Mol. Cell Biol. 20, 8244–8253 (2000).

    Article  CAS  Google Scholar 

  7. Debnath, J. & Brugge, J.S. Nature Rev. Cancer 5, 675–688 (2005).

    Article  CAS  Google Scholar 

  8. Muthuswamy, S.K. et al. Nature Cell Biol. 3, 785–792 (2001).

    Article  CAS  Google Scholar 

  9. Debnath, J. et al. Cell 111, 29–40 (2002).

    Article  CAS  Google Scholar 

  10. Guo, W. et al. Cell 126, 489–502 (2006).

    Article  CAS  Google Scholar 

  11. Muller, W.J. et al. Cell 54, 105–115 (1988).

    Article  CAS  Google Scholar 

  12. Ozdamar, B. et al. Science 307, 1603–1609 (2005).

    Article  CAS  Google Scholar 

  13. Liu, H., Radisky, D.C., Wang, F. & Bissell, M.J. J. Cell Biol. 164, 603–612 (2004).

    Article  CAS  Google Scholar 

  14. Muthuswamy, S.K. Cell 126, 443–445 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, 02115, MA, USA

    Stephanie J. Walker & Joan S. Brugge

Authors
  1. Stephanie J. Walker
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Joan S. Brugge
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Walker, S., Brugge, J. SePARating polarity and proliferation in ErbB2 oncogenesis. Nat Cell Biol 8, 1220–1222 (2006). https://doi.org/10.1038/ncb1106-1220

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncb1106-1220

  • Springer Nature Limited

Search

Navigation